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  • 标题:ポリエチレン多孔質中空糸膜による飲料水中変異原の吸着と吸着変異原の若干の性質
  • 本地全文:下载
  • 作者:橋爪 崇 ; 横山 剛 ; 沢田 洋介
  • 期刊名称:Journal of Health Science
  • 印刷版ISSN:1344-9702
  • 电子版ISSN:1347-5207
  • 出版年度:1985
  • 卷号:31
  • 期号:6
  • 页码:385-390
  • DOI:10.1248/jhs1956.31.385
  • 语种:Japanese
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:

    A membrane of microporous polyethylene hollow fibers (EHF membrane) has often been used to prepare sterilized water in medical institutions. In the present investigation, we have studied the capacity of EHF membrane to adsorb mutagens from drinking water and examined some properties of the mutagens. Through the module of EHF membrane, drinking water of three cities (A, B and C) was passed and the adsorbate extracted with methanol. The methanol extract was dissolved in dimethylsulfoxide and tested for the mutagenicity to Salmonella typhimurium TA 100, TA 98 and TA 1537 with and without S9 mix. All the extracts showed mutagenic activities to these three tester strains, and it was demonstrated that the EHF membrane has a capacity to adsorb mutagens from drinking water. The mutagenic activities of the extracts decreased by the addition of S9 mix to these test systems. When the adsorption ability of EHF membrane was compared to that of the activated charcoal, the ability of the former was about 4.6 times higher than that of activated charcoal. Mutagens adsorbed of EHF membrane were soluble in most organic solvents, especially in ethyl ether. When the methanol extract was separated into acidic, basic and neutral fractions with ethyl ether, the neutral fraction showed the highest mutagenic activity. The mutagens adsorbed to EHF membrane were relatively stable to heat.

  • 关键词:EHF membrane;adsorbate;mutagenicity;Ames assay;drinking water;activated charcoal
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