摘要：To find the mechanism of indirect action of lead on the body, movement of trace metals in the liver of rats intoxicated with lead acetate was examined. Lead acetate was dissolved in distilled water to a concentration of 20 mg/ml as lead ion. The solution (1.0 ml/kg) was administered intraperitoneally once to rats. Some trace metals (Ca, Fe, Zn, Mg, Mn, and Cu) in the liver was quantitatively determined using chloric acid digestion by atomic absorption spectrophotometry. No significant difference was found in the amount of Cu, Zn, Mg, and Mn in the liver of rats between the lead-poisoned group and the control group, but the content of calcium in the liver of rats treated with lead acetate increased 25.77 times (p<0.001) and the content of iron decreased about one-third (p<0.01) compared with normal rats. In the case of administration of stannous acetate, zinc acetate, manganese acetate, or calcium acetate, no significant difference was found in the amount of calcium in the liver between the matal-treated and normal rats. The content of calcium in the kidneys of rats treated with stannous acetate increased 6.19 times (p<0.01) compared with normal rats, and then the kidneys changed into white. After a single intraperitoneal administration of lead acetate, the amount of calcium in the liver reached a maximum after 72 hr, and deposition of calcium increased rapidly and linearly in proportion to the amount of lead adminisered.
