摘要：Colorimetric determination of phenacetine and bucetine in mixed pharmaceutical preparations was examined. Phenacetine and bucetine reacted with nitric acid-acetic acid-0.1% sodium nitrate solution (30 : 20 : 0.1) to give a yellow color. These chromogens could be extracted into chloroform and showed absorption maximum at 392 and 390 mμ, respectively. Presence of acetaminophene, salicylamide, pyrazolone, potassuim guaiacolsulfonate, glycerylguaiacolether, and ascorbic acid interfered with this determination but they could be eliminated by extraction with ethyl acetate in basic or acidic medium.
