摘要：The inhibition of human serum cholinesterase by lysergic acid diethylamide (LSD), lysergic acid amide (LAA), isolysergic acid amide (iso-LAA), lysergol and elymoclavine was investigated, acetylcholine was used as a substrate. The enzyme activity was assayed by colorimetric determination of residual acetylcholine in the incubation mixture. The 50 percent inhibition of the cholinesterase activity in human serum was observed with 6×10-4μM LSD, 3×10-2μM elymoclavine and 1×10-1μM lysergol. Only 20 per cent inhibition occurred with concentration of LAA or iso-LAA up to 2×10-1μM. These alkaloids were the competitive inhibitors of the enzyme to acetylcholine.
