摘要：When rats were orally given 500μmoles per kg of phenobarbital, the plasma level of corticosterone is not exhibited to be significantly changed. At 25 hours after pretreatment with phenobarbital, the activity of demethylation of methylbabital is markedly increased, but the demethylation of morphine and meperidine are not. The corticosterone level of plasma in rats which were pretreated with morphine intraperitoneally with a daily dose of 80 mg per kg was increased except the first day, while the activity of demethylation of meperidine and morphine was continued to decrease with chronic administration of morphine.
