摘要：Some hypoxanthine derivatives which were substituted at C8-position by hydrophilic groups such as-SH, -S-CH2-COOH, -COOH, -CH2OH and-CH2-CH2-COOH were synthesized for testing purine-antagonist action. They were prepared by condensation of 4, 5-diamino-6-hydroxypyrimidine (I) with the corresponding acid or amide compounds through the acyl derivatives of (I). A direct preparation of 4-amino-6-hydroxypyrimidine by reaction of malonamamidine with ethyl formate was also described.
