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  • 标题:Chemicopharmacological Studies on Antispasmodic Action. VII. Antagonism to Acetylcholine tested with Rectus Abdominis of Frog.
  • 本地全文:下载
  • 作者:Keijiro Takagi ; Issei Takayanagi
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:1957
  • 卷号:5
  • 期号:3
  • 页码:247-253
  • DOI:10.1248/cpb1953.5.247
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:It was concluded statistically on the contraction of rectus abdominis of a frog that : 1) The reaction between ACh and its receptor in the muscle obeyed Clark's formula and the reaction order was 1, that is, they react with one molecule each. 2) Reaction mechanism between ACh and its receptor was different in the presence of eserine, from that in its absence. 3) Antagonism of atropine and d-tubocurarine to ACh obeyed Gaddum's formula as competitive. 4) One molecule of d-tubocurarine antagonized two mo■ecules of ACh ; two ammonium nitrogens in d-tubocurarine antagonized one molecule of ACh each.
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