标题：Metabolism of Drugs. X. The Relationship between Hypnotic Activity and Metabolism of Ethylhexabital. (1) The Influence of Species, Sex, and Age on the Activity of Liver to Metabolize Ethylhexabital and the Isolation of an in vitro Metabolite.
摘要：The isolation of an in vitro metabolite of ethylhexabital (EHB) and its identification as 3-keto-EHB were described. It was found that there was an inverse relationship between the duration of EHB hypnosis and the EHB-metabolizing activity of liver slices. Of the animal species used in this study, the adult male rat slept for the shortest period and most rapidly metabolized EHB and vice versa for the guinea pig. The sex difference in the duration of EHB hypnosis and EHB-metabolizing activity of liver slices were found only in the adult rat. The liver of male rats more rapidly metabolized EHB than that of female rats.
