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  • 标题:Studies on the Syntheses of Hydrogenated Quinolines and Isoquinolines as Analgesics. XIII. Synthesis of 3-Hydroxy-N-methyl-6-aza-des-N-morphinan (N-Methyl-9-hydroxy-5, 10b-trimethylene-1, 2, 3, 4, 4a, 5, 6, 10b-octahydrobenzo [h] isoquinoline).
  • 本地全文:下载
  • 作者:Norio Sugimoto ; Susumu Ohshiro
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:1957
  • 卷号:5
  • 期号:4
  • 页码:316-319
  • DOI:10.1248/cpb1953.5.316
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:3-Hydroxy-N-methyl-6-aza-des-N-morphinan was synthesized in accordance with the methods described earlier but the compound failed to show any analgesic activity. However, it had antitussive action somewhat weaker than that of codeine.
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