标题:Studies on the Syntheses of Hydrogenated Quinolines and Isoquinolines as Analgesics. XIII. Synthesis of 3-Hydroxy-N-methyl-6-aza-des-N-morphinan (N-Methyl-9-hydroxy-5, 10b-trimethylene-1, 2, 3, 4, 4a, 5, 6, 10b-octahydrobenzo [h] isoquinoline).
摘要:3-Hydroxy-N-methyl-6-aza-des-N-morphinan was synthesized in accordance with the methods described earlier but the compound failed to show any analgesic activity. However, it had antitussive action somewhat weaker than that of codeine.