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  • 标题:Studies on Antibiotics. XVI. Isolation and Identification of Dihydrostreptomycin produced by a New Streptomyces, Streptomyces humidus nov. sp.
  • 本地全文:下载
  • 作者:Sueo Tatsuoka ; Tsunaharu Kusaka ; Akira Miyake
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:1957
  • 卷号:5
  • 期号:4
  • 页码:343-349
  • DOI:10.1248/cpb1953.5.343
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Isolation and chemical studies were carried out on an antibiotic which was produced by a new streptomyces, Streptomyces humidus nov. sp. From the physical, chemical, and microbiological properties of this antibiotic in crude state, it was found that this antibiotic belonged to the so-called streptomycin-group antibiotics, but differed from streptomycin, mannosidostreptomycin, and hydroxystreptomycin, which are produced directly by streptomycetes. This antibiotic was finally isolated as a pure crystalline sulfate. The physicochemical and microbiological properties of this sulfate and physicochemical properties of its degradation products showed that this sulfate was nothing but dihydrostreptomycin sulfate.
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