标题：Metabolism of Drugs. VI. The Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3, 5-dimethylbarbituric Acid).(2).3) On the Chromic Oxidation of Methylhexabital and Normethylhexabital (5-Cyclohexenyl-5-methylbarbituric Acid)
摘要：Chromic oxidation of MHB (5-cyclohexenyl-3, 5-dimethylbarbituric acid) and nor-MHB (5-cyclohexenyl-5-methylbarbituric acid) were undertaken in order to compare with the metabolic products of MHB. As the oxidation products of MHB, 5-(3'-oxocyclohex-1'-enyl)- and 5-(6'-oxocyclohex-1'-enyl)-3, 5-dimethylbarbituric acid were obtained and principally 5-(3'-oxocyclohex-1'-enyl)-5-methylbarbituric acid was obtained as that of nor-MHB. Their chemical structures were confirmed by their degradation experiments, in which cyclohexenyl groups were dehydrogenated to phenol groups and further converted to the corresponding hydroxybenzoic acid by an oxidative alkali fusion.
