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  • 标题:Metabolism of Drugs. VII.1) The Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3, 5-dimethylbarbituric Acid).(3).1) Isolation, Characterization, and Identification of Metabolic Products of Methylhexabital
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  • 作者:Hisao TSUKAMOTO ; Hidetoshi YOSHIMURA ; Satoshi TOKI
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:1956
  • 卷号:4
  • 期号:5
  • 页码:368-371
  • DOI:10.1248/cpb1953.4.368
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:The three metabolites of methylhexabital (5-cyclohexenyl-3, 5-dimethylbarbituric acid) were isolated from the urine of rabbits receiving MHB and their structures were established as cyclohexenylmethyl-N-methylacetylurea, and 5-(3'-oxocyclohex-1'-enyl)- and 5-(3'-hydroxycyclohex -1'-enyl)-3, 5-dimethylbarbituric acid. Their yield was about 0.5%, 1%, and 5% of the dose administered, respectively.
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