标题：Studies on the Syntheses of Isoquinoline Derivatives and their Analogs. XXXVII. A New Method for the Preparation of 1-Substituted 3-Methyl-3, 4-dihydroisoquinoline Derivatives by the Reaction of Allylbenzene and Heterocyclic Acid Amide or Oxime
摘要：Reactions of various heterocyclic aldoximes and acid amides with methyleugenol or safrole, by utilization of the new isoquinoline synthesis (Kametani procedure1∼5)) gave the objective 1-substituted 3-methyl-6, 7-dimethoxy (or 6, 7-methylenedioxy)-3, 4-dihydro-isoquinoline, but the yield was generally less than 30%. The acid amides used were furan-and thiophene-2-carboxylic amides, and 4-methylthiazole-5-carboxylic amide. As the oxime, 2-furfuraldoxime was used, but the use of pyridine-carboxylic amide did not give the objective and unexpectedly cyanopyridine was obtained.
