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  • 标题:Chemicopharmacological Studies on Antispasmodic Action. VI. On Statistical Treatment of Concentration-Action Relationship of Acetylcholine on Small Intestines of Mice.
  • 本地全文:下载
  • 作者:Keijiro Takagi ; Masayasu Kimura
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:1956
  • 卷号:4
  • 期号:6
  • 页码:449-453
  • DOI:10.1248/cpb1953.4.449
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:1) A concentration-action relationship of acetylcholine was demonstrated using isolated intestines of 20 mice. 2) For mean responses of six acetylcholine concentrations was fitted a logistic sigmoid curve by the method of maximum likelihood. 3) The maximum likelihood estimate of the mean slope was 1.146, which was proved not to be significantly different from the theoretical value of one.
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