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  • 标题:薬物の裁判化学的研究(第1報)水性除草剤中におけるDiquatならびにParaquatのガスクロマトグラフィーによる定量
  • 本地全文:下载
  • 作者:鵜飼 茂夫 ; 広瀬 一雄 ; 河瀬 章司
  • 期刊名称:Journal of Health Science
  • 印刷版ISSN:1344-9702
  • 电子版ISSN:1347-5207
  • 出版年度:1973
  • 卷号:19
  • 期号:5
  • 页码:281-286
  • DOI:10.1248/jhs1956.19.281
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:A gas chromatographic method is described for determinig diquat (I) and paraquat (II), separately and simultaneously, in aqueous herbicide preparations. Analysis of I and II was performed by gas chromatography (detector : HFID) of their reduction products, which were derived by treatment with sodium borohydride. The ethyl acetate solutions of the reduction-products were injected into the gas chromatograph apparatus equipped with a glass column containing Gas-Chrom Z coated with 5% KOH and 5% PEG-6000 at 180° (usual determination) or 165° (simultaneous determination). These conditions were found to result in the satisfactory separation of the reduction products of I and II. This procedure is well suited forthe assay of 5-65 μg/ml concentration of I and II (internal standard substance : o-phenylenediamine). The main compounds isolated from the reduction-products of I and II were presumed on the basis of the results of nuclear magnetic resonance and mass spectra, and from elementary analysis to be N, N'-ethylene-1, 1', 2, 2', 3, 3', 6, 6'-octahydro-6, 6'-bipyridyl (III) and N, N'-dimethyl-1, 1', 2, 2', 3, 3', 6, 6'-octahydro-4, 4'-bipyridyl (IV), respectively.
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