摘要：New optically active stereoisomers of santonin were synthesized and their absolute configurations investigated. It has been shown that(-)-6α-hydroxy-3-oxo-11-epi-isoeusatona-1, 4-dienic acid lactone, (-)-6β-hydroxy-3-oxoeusantona-1, 4-dienic acid lactone, and (-)-6β-hydroxy-3-oxo-11-epi-eusantona-1, 4-dienic acid lactone are of the same stereochemical type as that of the naturally occurring santonins. An aspect of the mechanism of the dienone-phenol rearrangement in santonin series was also considered.
