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  • 标题:Studies on the Biosynthesis of Nucleic Acids. II. On the Role of Antimetabolites as an Inhibitor of Polynucleotide Biosynthesis
  • 本地全文:下载
  • 作者:Teruhisa Noguchi
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:1956
  • 卷号:4
  • 期号:2
  • 页码:97-100
  • DOI:10.1248/cpb1953.4.97
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:The effect of 4-aminotriazole-5-carboxamide and certain purine antimetabolites (e.g. 8-azaguanine, 6-mercaptopurine, and 2, 6-diaminopurine) as well as folic acid antimetabolites (e.g. aminopterin) on the incorporation of labeled 4-aminoimidazole[4-14C]-5-carboxamide, formate-14C, and 32P into polynucleotides of rat or pigeon liver slices was demonstrated and certain aspects of their mode of action were discussed.
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