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  • 标题:Oxidation of 3-Substituted 1-Alkylpyridinium Salt. III. Preparation of 1-methyl-3-ethyl-6-pyridone and-piperidone
  • 本地全文:下载
  • 作者:Shigehiko Sugasawa ; Makoto Kirisawa
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:1955
  • 卷号:3
  • 期号:3
  • 页码:190-193
  • DOI:10.1248/cpb1953.3.190
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:1-Methyl-3-acetyl-6-pyridone (VIII) was prepared. Though quaternary metho-salt of 3-acetylpyridine did not undergo smooth oxidation with alkaline ferricyanide, the corresponding ethylene-ketal (VIa) was oxidized smoothly, giving 1-methyl-3-acetyl-6-pyridone ethylene-ketal (VIIa) in ca.85% yield. The latter was hydrolyzed in dilute acid to give 3-acetyl compound (VIII) in quantitative yield. Huang-Minlon reduction converted the latter into 1-methyl-3-ethyl-6-pyridone (X) in a fair yield, from which the corresponding piperidone (XI) was obtained by catalytic hydrogenation over Raney nickel. Wolfrom and Karabinos method applied to di(ethylthio) compound (XIII) of (VIII) gave a mixture of (X) and (XI), of which the latter was formed predominantly. For the direct synthesis of (XI), oxidation of ethylenedithio compound of 1-methyl-3-acetyl-pyridi nium salt (VIb) was preferred to furnish the corresponding 6-pyridone (VIIb), which was directly desulfurized according to the method of Wolfrom and Karabinos to yield(XI).
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