摘要：A cyclization of β-chloroethyl group of N-bis(β-chloroethyl) amino acids and their N-oxides in a dilute aqueous solution was discussed in this paper. The intermediates formed in the solution, viz., ethyleneimonium ions from the tertiary amines or 1, 2-dimethyleneoxaimonium ions (oximonium ions) from the N-oxides, were found to be less stable and more readily subjected to hydrolysis than that of methyl-bis (β-chloroethyl)amine and its N-oxide.
