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  • 标题:Studies in Stereochemistry. IV. Alkanolamines. (4). (Regular dl-2, 5-Diphenyl-4-methyloxazoline : The Formation and Action of Methyl Tosylate.
  • 本地全文:下载
  • 作者:Tanezo Taguchi ; Masaharu Kojima
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:1955
  • 卷号:3
  • 期号:1
  • 页码:4-7
  • DOI:10.1248/cpb1953.3.4
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Of the two forms of dl-2, 5-diphenyl-4-methyloxazolines, the ψ-form has been obtained, but not the regular form. Therefore, the formation of the latter was studied and was successfully obtained by two ways, the one being based on the reaction between dl-norephedrine and benzimidoethyl ether hydrochloride, and the other on the treatment of dl-ψ-1-phenyl-1-chloro-2-benzoylaminopropane with boiling absolute ethanol containing anhydrous sodium carbonate. Further, the regular oxazoline was reacted with methyl tosylate and yielded dl-O-benzoylephedrine tosylate. The purpose of the reaction was to find and example of the new method of N-monoalkylation of β-amono-alcohols, which was reported in the previous papers.1, 3, 4)
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