摘要：Effects of cholecystokinin on metallothionein in mice were studied. The total amount of metallothionein in the mouse pancreas increased after the injection of cholecystokinin. The increase was dose-dependent and a positive relationship was observed between amylase activity in the serum and the total amount of metallothionein in the pancreas. A pre-injection of zinc, cadmium or benzene depressed the increase of the serum amylase activity after the injection of cholecystokinin. In the case of pre-induced MT, a negative relationship was found between metallothionein concentration in the pancreas and amylase activity in the serum. These results indicate that the metallothionein concentration in the mouse pancreas increased after the injection of cholecystokinin, and suggest that metallothionein in the pancreas may protect the pancreas against acute pancreatitis caused by cholecystokinin.
