摘要：Effects of rare earth elements (REEs) on the time courses of REE, Ca, Mg and P concentrations in the liver, kidney, spleen, lung, femur and whole blood were investigated in the male rats of Wistar strain. Four kinds of REE salts, i.e. dysprosium chloride (DyCl3), europium chloride (EuCl3), ytterbium chloride (YbCl3) and yttrium chloride (YCl3)], were administered intravenously from the caudal vein (10 mg/kg as REE). Contents of REE, Ca, Mg and P were estimated by the wet digestion-ICP-AES method as a function of time. Results were as follows : 1) Concentrations of Ca in the liver, spleen and lung increased extremely in the rat administered with YCl3. Pattern of hepatic Ca concentration as a function of time was similar to that of hepatic Y concentration, and Ca concentration was not significantly different from the control group at 45th d after the administration. Patterns of Ca concentrations were different from Y in the spleen and lung. REEs administration did not affect significantly the concentrations of Ca, Mg and P in the liver, kidney, spleen and lung except the concentrations of Ca in the liver, spleen and lung of Y-administered rats. 2) Concentrations of Ca, Mg and P in the whole blood of REE-administered rats varied from the control group within 1 d after the administration. 3) No significant effects were observed in the femoral Ca, Mg and P concentrations. 4) Concentrations of REEs in the whole blood and liver decreased exponentially in the ranges of 15 min-1 d and 1-45 d (8 h-45 d in case of YCl3-administered rats) respectively. The half lives of Dy, Eu, Yb and Y were calculated as 6.94, 6.78, 6.84 and 0.427 h for the whole blood, and 16.2, 21.0, 15.5 and 19.3 d for the liver, respectively.
