摘要：We investigated the effect of vitamin E on active oxygen generation by alveolar macrophages (AMs) challenged with different stimuli to determine the influence of the vitamin. AMs were obtained from rats orally treated with vitamin E (100 mg/kg or 150 mg/kg) for 6 d, and Concanavalin A (Con A) and 12-o-tetradecanoylphorbol-13-acetate (TPA) were used as stimuli. AMs from the vitamin E-treated group showed a dose-dependent increase of active oxygen generation when stimulated with Con A. while a dose-dependent decrease of production by AMs challenged with TPA was observed with the vitamin treatment. These results suggest that vitamin E has a modulating effect on active oxygen production by AMs stimulated with stimuli.
关键词：modulating effect;vitamin E;active oxygen;alveolar macrophage;stimulus;Concanavalin A
