摘要：To investigate the influences of unsaturated fatty acids on hemoglobin, one saturated, stearic acid, and five unsaturated, linoleic, linolenic, arachidonic, eicosapentaenoic and docosahexaenoic acids, known as the constituents of various marine organisms, were examined. All unsaturated fatty acids changed oxyhemoglobin to methemoglobin in vitro, whereas no change was observed with saturated fatty acid. This change of oxyhemoglobin to methemoglobin observed with both ester and free types of unsaturated fatty acids as clearly inhibited by the addition of α-tocopherol. It is suggested that the change of hemoglobin to methemoglobin observed with authentic unsaturated fatty acids is highly related to the autooxidation of the polyenoic fatty acids.
