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  • 标题:フェノキシ系除草剤2,4-Dichlorophenoxy acetateのガスクロマトグラフィーによる裁判化学的研究
  • 本地全文:下载
  • 作者:竹腰 裕二 ; 管野 進 ; 河瀬 章司
  • 期刊名称:Journal of Health Science
  • 印刷版ISSN:1344-9702
  • 电子版ISSN:1347-5207
  • 出版年度:1991
  • 卷号:37
  • 期号:4
  • 页码:276-280
  • DOI:10.1248/jhs1956.37.276
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Accidental and suicidal poisonings with sodium 2, 4-dichlorophenoxy acetate (2, 4-D-Na) have occurred occasionally in the fields of forensic toxicology. The gas chromatographic method for the determination of 2, 4-D-Na involving the preparation of the n-propyl ester was studied. 2, 4-D-Na was directly converted with n-propanol-boron-trifluoride to the n-propyl ester which was measured by gas chromatography, although the esterifications so far have been carried out after being led to its free acid. Sep-pak C18 cartridge was applied to the simple and rapid extraction of 2, 4-D-Na from the urine in the following matter, a urine sample was adjusted to pH 7.0, poured into a Sep-pak C18 cartridge, 2 ml of H2O-methanol (75 : 25, v/v) was put into the cartridge to selectively eliminate urinary components and finally 2 ml of H2O-methanol (20 : 80, v/v) was poured into the cartridge to elute 2, 4-D-Na, at a constant rate of flow, 5 ml/min. 2, 4-D-Na was satisfactorily recovered and no interference was observed for gas chromatography after esterification. This method is more efficient, simple, and less time-consuming than previous described methods.
  • 关键词:sodium 2, 4-dichlorophenoxy acetate;n-propanol-boron-trifluoride;gas chromatography;direct esterification;Sep-pak C18 cartridge;urine;n-propyl ester
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