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  • 标题:2種類の溶融シリカキャピラリーカラム付きガスクロマトグラフィーを用いた薬物の検索システム
  • 本地全文:下载
  • 作者:土橋 均 ; 小野 広孝 ; 辰野 道昭
  • 期刊名称:Journal of Health Science
  • 印刷版ISSN:1344-9702
  • 电子版ISSN:1347-5207
  • 出版年度:1988
  • 卷号:34
  • 期号:3
  • 页码:256-265
  • DOI:10.1248/jhs1956.34.256
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Drugs and pesticides (129 compounds) of abuse have been analysed simultaneously by a capillary gas chromatograph with dual fused-silica column having different polarity and retention index data have been compiled for these compounds. By installing two differently coated columns with a split adapter in the same injector and connecting these column ends to flame ionization detectors (FID), the simultaneous gas chromatographic analysis of these compounds was accomplished. Two fused silica columns were CBP-1 and CBP-10 (0.2 mm i.d.×50 m, film thickness 0.25μm). The column temperature increased from 100°C to 320°C at 10°C/min, the detector and injector temperature was 280°C. Discriminating power (DP) was 0.993 with combination of two columns (error factor=30). Retrieval system was developed through the use of a retention index library and the program of this system was written with BASIC. A summary of the BASIC program used for retention index calculation and library seach is included. Furthermore, it was possible to estimate the molecular weights and to specify compounds with retention index by using this system.
  • 关键词:fused-silica capillary column;GC;retrieval system;discriminating power;retention index;drug
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