摘要：An extraction and clean-up flow system using continuous liquid-liquid partition and a disposable octadecyl silane cartridge was devised for the determination of preservatives in cosmetics. The system was applied to determine p-hydroxybenzoate esters (parabens) in cosmetics such as shampoos, hair rinses, creams, etc. containing surfactants which cause emulsification difficulties in the usual shaking extraction. Parabens were extracted with a steady stream of droplets of diethyl ether from a sample in a glass tube and purified by passing through a Sep-Pak C18 cartridge. High performance liquid chromatography was used for the determination. Parabens were separated on a Inertsil ODS column by using methanol-water (2 : 1, v/v) as a mobile phase and detected at 254 nm. The present method was found to be simple and rapid with sufficient accuracy and precision. It was applicable to determine parabens in cosmetics containing surfactants.
