摘要：Effects of cosmetic UV absorbers on UV-induced mutagenesis in E. coli B/r strains were studied. Among 8 substances tested, cinoxate (2-ethoxyethyl p-methoxycinnamate) enhanced UV (254 nm)-induced mutation at non-lethal toxic doses. This adverse effect was also observed when the mid and near-UV (295 nm-400 nm) irradiated cells of WP2 were used. This effect, however, was not observed in WP2s uvr A, a DNA excision repair deficient strain of E. coli B/r. It is thus assumed that cinoxate inhibited DNA excision repair system and consequently increased UV-induced mutation.
