摘要:Several cases of the patients with allergic contact dermatitis caused by an athletic tape and sneakers were reported. In patch testing p-tert-butylphenol formaldehyde resin (PTBP-FR) was found to be reactive to these patients. Therefore, analytical procedures including gas chromatography (GC), GC-mass spectrometry (GC-MS) and high performance liquid chromatography (HPLC) were developed to determine PTBP-FR and p-tert-butlyphenol (PTBP), which is a material for the synthesis of PTBP-FR, in such commercially available household products as adhesive tapes, shoes and adhesives for rubber and leather. PTBP and PTBP-FR were detected in both of the causative athletic tape and adhesive spread onto the inner lining of the sneakers. However, neither of 16 other brands of adhesive tapes nor 8 brands of the inner cushions of shoes contained PTBP and PTBP-FR. On the other hand, 7 out of 8 brands of adhesives for rubber and leather contained 0.005-0.242% of PTBP and 0.104-1.67% of PTBP-FR. From these results, it was concluded that PTBP-FR should be a causative chemical in both cases of contact dermatitis, and PTBP-FR should be given much attention as a candidate of causative chemicals in contact dermatitis from rubber and leather products.