摘要：This review describes the contribution of metal compounds to carcinogenicity and anticancer from four standpoints as follows : (1) For each metal that has been reported or suspected to be carcinogenic, human epidemiology, animal cancer tests, mutagenesis, and in vitro cell transformation were surveyed. (2) Anticarcinogenic action of metals with a suppressive effect on chemical carcinogenesis in animals was surveyed. These roles of metals belong to a concept of chemoprevention and are known to have some suppressive effects on tumor induction and development. (3) Behaviors of essential trace metals related with chemical carcinogenesis and in tumor-bearing animals were briefly surveyed. (4) Antitumor activity of such metal complexes as cisdiamminedichloroplatinum (II), containing complexes of platinum, copper, ruthenium, rhodium, titanium, palladium, stannum, and gold as anticancer agents, was surveyed.
