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  • 标题:The Effect of Several Antipyretic Analgesics on Mitomycin C-Induced Mutagenesis Using the Wing Spot Test in Drosophila melanogaster
  • 本地全文:下载
  • 作者:TAKAHIKO SATO ; KOUITI NAGAOKA ; HISAMITSU NAGASE
  • 期刊名称:Journal of Health Science
  • 印刷版ISSN:1344-9702
  • 电子版ISSN:1347-5207
  • 出版年度:1996
  • 卷号:42
  • 期号:2
  • 页码:136-141
  • DOI:10.1248/jhs1956.42.136
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:The effect of several antipyretic analgesics on mitomycin C-induced mutagenesis was investigated using the wing spot test in Drosophila melanogaster. Aspirin, ibuprofen and indomethacin showed strong antimutagenicity, while the antimutagenicity of acetaminophen and ethenzamide were weaker. Aspirin inhibited chromosome recombination. A considerable part of the antimutagenicity of aspirin, ibuprofen and indomethacin can be explained by bioantimutagenicity.
  • 关键词:antimutagenicity;bio-antimutagenicity;chromosome recombination;antipyretic analgesic;wing spot test;Drosophila melanogaster
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