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  • 标题:市販黄色5号の不純物のショウジョウバエ毒性試験
  • 本地全文:下载
  • 作者:河井 一明 ; 古川 秀之 ; 椛澤 洋三
  • 期刊名称:Journal of Health Science
  • 印刷版ISSN:1344-9702
  • 电子版ISSN:1347-5207
  • 出版年度:1993
  • 卷号:39
  • 期号:4
  • 页码:332-335
  • DOI:10.1248/jhs1956.39.4_332
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Commercial Food Yellow No.5 showed genotoxic activity in Drosophila wing spot test. Seventy-two hours larvae of Drosophila were treated chronically (during the whole third larval instar) with commercial Food Yellow No.5. The frequencies of single spots increased 4-fold that of control. Commercial Food Yellow No.5 involved some impurities. Impurity fraction A, which contained more polar compounds than Food Yellow No.5, showed DNA damage in Drosophila DNA-repair test. These results suggested that the impurities would be contributed to the genotoxicity of commercial Food Yellow No.5.
  • 关键词:Drosophila melanogaster;wing spot test;DNA-repair test;Food Yellow No.5;genotoxicity;somatic mutation
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