摘要：The interaction of cannabinoids, tetrahydrocannabinol (THC), cannabidiol (CBD) and some active metabolites with thinner and its components was studied in mice and the following results were obtained. 1) Δ9-THC but not CBD (5 mg/kg, i.v.) significantly prolonged thinner-induced anesthesia by 1.8 fold. The latent period to induce the anesthesia was significantly shortened by Δ9-THC. 2) 11-Hydroxy-Δ8-THC and 11-oxo-Δ8-THC (5 mg/kg, i.v.), which are active metabolites of Δ8-THC, significantly prolonged thinner-induced anesthesia by 2.0 and 3.2 fold, respectively. 11-Oxo-Δ8-THC significantly shortened latent period to induce the anesthesia. 3) Among cannabinoids examined, only 11-hydroxy-Δ8-THC significantly prolonged toluene-induced anesthesia by 2.4 fold. Thinner contains about 60% of toluene and a small amount of ethyl acetate, ethylether and ethylalcohol. 4) Δ8-THC and its active metabolites, 11-hydroxy-Δ8-THC and 11-oxo-Δ8-THC significantly prolonged ethyl acetate-induced anesthesia by 4.4, 4.9 and 5.1 fold, respectively. Moreover, Δ8-THC, 11-hydroxy-Δ8-THC and 11-oxo-Δ8-THC significantly shortened latent period to induce anesthesia.
关键词：Δ9-tetrahydrocannabinol;Δ8-tetrahydrocannabinol;cannabidiol;active metabolite;thinner;toluene;ethyl acetate;anesthesia in mice
