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  • 标题:Genotoxicity of 2-Amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP) in Drosophila melanogaster and Enhancement of DNA Damaging Activity by Pretreatment with β-Naphthoflavone and Ethanol
  • 本地全文:下载
  • 作者:Terue KASAI ; Takeshi KITAMURA ; Yuko TAKAHASHI
  • 期刊名称:Journal of Health Science
  • 印刷版ISSN:1344-9702
  • 电子版ISSN:1347-5207
  • 出版年度:1998
  • 卷号:44
  • 期号:1
  • 页码:34-41
  • DOI:10.1248/jhs1956.44.34
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:The genotoxicity of 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP) was assayed by the wing spot test for detecting somatic cell mutations and the DNA-repair test for detecting DNA damage with Drosophila melanogaster. Although PhIP increased the frequency of small single spots in a dose-dependent manner in the wing spot test, no large single spots and twin spots were induced to a significant extent. In the DNA-repair test PhIP showed clear DNA-damaging activity. The DNA-damaging potency of PhIP was significantly increased when larvae were pretreated with β-naphthoflavone (BNF) 24-48 h after oviposition. Excessive reduction of the Rec- male/Rec+ female ratio was also observed in ethanol-pretreated stock compared with stock not pretreated. These results indicate that alcohol and BNF, both enzyme inducers, enhance the in vivo DNA-damaging activity of PhIP.
  • 关键词:2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine;Drosophila melanogaster;ethanol;β-naphthoflavone;mutagenicity
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