摘要：After single oral administration of 14C-α-bromocinnamaldehyde (14C-α-BCA) to rats, a peak of radioactivity in blood was observed at 3 h and a high level was observed until 12 h. Among the organs and tissues, high radioactivity was found in liver and kidney until 96 h after dosing. About 27 and 70% of dosed radioactivity were excreted in feces and urine within 48 h, respectively. As urinary metabolites, hippuric acid, α-bromocinnamoylglycine, α-bromocinnamic acid and α-bromocinnamyl alcohol were identified. Daily oral dosing for 7 d did not reveal any accumulation in any particular organ, compared with the result after single dosing. When radioactive bile from rats administered 14C-α-BCA was injected into the duodenum of another rat, about 33% and 42% of the radioactivity were excreted within 48 h in bile and urine, respectively, via enterohepatic circulation.
