出版社：Japanese Society of Nutrition and Food Science
摘要：The metabolism of circulating maltose or glucose was studied in guinea pigs. On the observation of excretion of radioactivity following intravenous administration of maltose-U-14C, 41% of the radioactivity was expired as respiratory 14CO2 for 5 hours and 52% for 12 hours, and only 4% was excreted in the urine. The percentage of maltose oxidized to CO2 and excreted in the urine were similar to those of glucose. On the observation of disappearance rate of maltose-U-14C intravenously administered, biological half life of maltose-U-14C was 26 minutes and was similar to that of glucose-U-14C. No change of plasma glucose levels was observed and no maltase activity was detected in plasma, although glucose-U-14C originated from maltose-U-14C appeared in plasma and its increasing tendency in concentration was observed until 30 minutes after administration. On the observation of tissue distribution of radioactivity following intraveneus administration of maltose-U-14C, distribution of radioactivity in the administration of maltose-U-14C were not similar to that in the administration of glucose-U-14C. From these results, it is suggested that intravenously administered maltose is gradually converted to glucose and then metabolized to tissue constituents ( ca . 50%) or to respiratory CO2 ( ca . 50%). Similar results were reported in rabbits and in human subjects. Hence, parenteral administration of maltose would be of clinical value.
