摘要：Female Jcl: ICR mice were fed the diet containing glucomannan (GM) or sodium alginate (Na-Alg) at 0, 0.5 or 2.5% level for 7 days. At the 7th day the animals were treated orally with a large dose of Cd (as cadmium chloride). The results obtained in mice fed the diet with 2.5% GM or Na-Alg are as follows: Oral LD50 values tended to decrease. Serum GOT and GPT activities were slightly elevated without Cd administration. Marked elevations in these enzyme activities 24 hours after a large dose of Cd (100mg Cd/kg, p. o.) tended to be enhanced by the ingestion of GM or Na-Alg. Serum urea nitrogen had a tendency to increase 24 hours after a large dose of Cd. Cadmium uptake by the liver and kidney 24 hours after a large dose of the metal significantly increased in the Na-Alg-fed mice and tended to increase in the GM-fed mice. Zinc concentration in the kidney increased in mice fed dietary GM, but that in the liver had a tendency to decrease in mice fed dietary Na-Alg 24 hours after a large dose of Cd. Both GM and Na-Alg were effective in reducing serum total cholesterol, but almost ineffective in reducing serum glucose. Propulsive motility of the small intestine 30 minutes after charcoal meal administration was not affected by the ingestion of GM or Na-Alg. Disadvantageous effects of dietary fibers after Cd administration were discussed when large amounts of dietary fibers were given.
