摘要：The first-order rate theory may be useful for estimation of the accumulation in the body in the experiments of consecutive administration. With this theory, the balance of lead in the human body was estimated in each case of 9, 13 and 17μg of daily lead absorption by assuming the ultimate limit of accumulation in the body is 80mg and that half-life time of hard tissues (bone, teeth) is 10 years. If 99 of the ultimate limit of accumulation is regarded as “actual ultimate limit of accumulation”, good results were obtained. The estimated parameters are following; the daily absorption of lead is 13 to 17μg, and the time to reach “actual ultimate limit of accumulation” is 60 to 78 years.
