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  • 标题:Determination of Clenbuterol in Pig Liver Following Prolonged Administration of a Growth-Promoting Dose
  • 本地全文:下载
  • 作者:Gojmerac, Tihomira ; Mandić, Božica ; Pleadin, Jelka
  • 期刊名称:Food Technology and Biotechnology
  • 印刷版ISSN:1330-9862
  • 电子版ISSN:1334-2606
  • 出版年度:2002
  • 卷号:40
  • 期号:4
  • 页码:343-346
  • 语种:English
  • 出版社:Sveuciliste u Zagrebu - Faculty of Food
  • 摘要:Liver concentrations of clenbuterol, a β2-adrenergic agonist, were measured by enzyme-linked immunosorbent assay (ELISA) in 12 female pigs on days 0, 7, 14 and 21 after prolonged administration of a growth-promoting dose of clenbuterol. The analytical procedure showed good recovery (>80 %), while intra-assay results showed acceptable variation in individual measurements for all samples to which 0.5, 2 or 5 ng/g clenbuterol were added (RSD 80 % clenbuterol depletion in pig liver occurred during the first 7 days after cessation of administration, however, more than 14 days were required for the clenbuterol concentration to fall below the maximal residual level of 0.5 ng/g. On day 21 of clenbuterol discontinuation, residues of the drug were detectable in pig liver (0.22 ng/g), suggesting that clenbuterol residues persist in liver as an edible tissue and may induce a risk for consumer health.
  • 关键词:β2-adrenergic agonist; residual clenbuterol; anabolic agent; enzyme immunoassay; pig liver
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