摘要：In order to achieve a good fit to real data that evolve over time and whose observed trend shows deviations with respect to an exponential shape, a non-homogeneous log-normal diffusion process with time dependent infinitesimal mean and variance is considered. Such model provides a more flexible structure of the variance than that of the non-homogeneous diffusion process only in its infinitesimal mean, allowing to reproduce the behaviour of the observed data more accurately and enable us to tackle problems in which data variability plays a fundamental role with a higher degree of reliability. A procedure for the estimation of the time functions included in the infinitesimal mean and variance is proposed and hypothesis testing to confirm or refute the need for considering non-homogeneous processes to fitting real data are designed. A simulation study corroborates the validity of the proposed estimation procedure. Finally, a real data application of a patient-derived xenograft (PDX) tumor model is performed.
