摘要：The article examines the first experience of creation of the Russian Empire of the sanitary affairs on the Caucasus in the middle – to late of the XVIII century. The attention is paid to the process of colonization, but also to the characteristic features of migrants’ life. As materials there were used the documents of the Central state historical archive of Georgia (Tbilisi, Georgia). The importance is given to the scientific publications on the topic of the study, published in pre-revolutionary and modern periods. In conclusion, the authors state that the Russian Empire is faced with multiple problemsduring its promotion on the Caucasus. At times one of them was the inability to choose places with healthy climate for settlements or forts.As a result, it was determined theexistence of significant casualties among the soldiers and representatives of the Russian administration from disease. Faced with these problems, the command began to strengthen the antiepidemic service of forces, authorized the establishment of hospitals and pharmacies. Thus, by the end of the XVIII century the Russian administration has started the systematic work on the creation of an extensive network of medical institutions in the Caucasus.
