期刊名称：Revue de Neuropsychologie Neurosciences Cognitives et Cliniques
印刷版ISSN：2101-6739
电子版ISSN：2102-6025
出版年度：2017
卷号：9
期号：2
页码：99-107
DOI：10.1684/nrp.2017.0418
出版社：John Libbey Eurotext
摘要：Limbic encephalitis (LE) used to be considered extremely rare, mainly associated with cancer, and unresponsive to treatment. Recently, many studies demonstrated that LE is more frequent than previously thought and that a substantial number of patients may recover. The symptoms are both neurologic and psychiatric such as loss of memory and anxiety. We present the case of a 62-year-old man (Mr. R.) that was characterized by subacute anterograde amnesia without seizure and preceded by a prodromal phase of asthenia and paroxysmal anxiety. Mr. R. also complained of prosopagnosia and topographical amnesia. LE AK5 (a known auto-antigen of LE) was identified as the target of antibodies in the CSFs and sera. Brain IRM showed bilateral hippocampal hyperintensities. CSF analysis showed a mild pleiocytosis with elevated immunoglobulin G index and oligoclonal bands. Hippocampal atrophy was observed on control brain MR. Clinical response to immunotherapy was poor, with persistence of severe anterograde amnesia. Mr. R. looked into the new operation of his memory and wrote “the submission of an oblivious patient”, which help him to share ideas and knowledge with his neurologist, for four years. We published sample texts.
