摘要：Photodynamic Therapy (PDT) has emerged as a useful cancer treatment modality which utilizes a tumor localizing dye and activating light to selectively destroy neoplastic tissue. In an effort to understand the newly synthesized photosensitizers, we are studying them in a mouse tumor model grown on the dorsal side of the foot by in vivo magnetic resonance techniques. We have synthesized several photosensitizers which are specifically labeled with fluorine. Several coils appropriate for the tumor study by 19F NMR were designed and constructed for this project. The solenoid coil tunable to both 1Hand 19F nuclei was used to monitor the 19F labeled photosensitizer in the mouse foot tumor. An in vivo 19F NMR technique was used to study the retention of the photosensitizer over time in the tumor. We have used 31P NMR to study the outcome of PDT after using the new photosensitizer.
