文章基本信息

标题：The Effect of Rivastigmine Transdermal Patch on Sleep Apnea in Patients with Probable Alzheimer's Disease
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作者：Kim, Hyeyun ; Han, Hyun Jeong
期刊名称：Dementia and Neurocognitive Disorders
印刷版ISSN：1738-1495
出版年度：2016
卷号：15
期号：4
页码：153-158
DOI：10.12779/dnd.2016.15.4.153
语种：English
出版社：KoreaMed Synapse
摘要：Background and Purpose
This study was designed to evaluate the effect on sleep of rivastigmine transdermal patch in patients with probable Alzheimer's disease (AD).
Methods
Patients with probable AD underwent a sleep questionnaire, overnight polysomnography and neuropsychological tests before and after rivastigmine transdermal patch treatment. We analyzed the data from enrolled patients with AD.
Results
Fourteen patients with probable AD were finally enrolled in this study. The respiratory disturbance index after the rivastigmine patch treatment was improved in patients with probable AD and sleep breathing disorder, compared with that of before treatment ( p <0.05).
Conclusions
Rivastigmine transdermal patch application are expected to improve the symptoms of sleep disordered breathing in patients with probable AD. Further placebo controlled studies are needed to confirm these results.
关键词：Alzheimer\'s disease; respiratory disturbance index; rivastigmine patch