文章基本信息

标题：Effect of Relaxin Expressing Adenovirus on Scar Remodeling: A Preliminary Study
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作者：Jung, Bok Ki ; Lee, Won Jai ; Kang, Eunhye 等
期刊名称：Archives of Craniofacial Surgery
印刷版ISSN：2287-1152
出版年度：2017
卷号：18
期号：1
页码：9-15
DOI：10.7181/acfs.2017.18.1.9
语种：English
出版社：KoreaMed Synapse
摘要：Background
Relaxin is a transforming growth factor β1 antagonist. To determine the effects of relaxin on scar reduction, we investigated the scar remodeling process by injecting relaxin-expressing adenoviruses using a pig scar model.
Methods
Scars with full thickness were generated on the backs of Yorkshire pigs. Scars were divided into two groups (relaxin [RLX] and Control). Adenoviruses were injected into the RLX (expressing relaxin) and Control (not expressing relaxin) groups. Changes in the surface areas, color index and pliability of scars were compared.
Results
Fifty days after treatment, the surface areas of scars decreased, the color of scars was normalized, and the pliability of scars increased in RLX group.
Conclusion
Relaxin-expressing adenoviruses improved the surface area, color, and pliability of scars. The mechanism of therapeutic effects on scar formation should be further investigated.
关键词：Gene Therapy; Cicatrix; relaxin; adenovirus