This study investigates the effect of competence, satisfaction, and discipline on performance of employees in the Office of Women Empowerment and Family Planning of Fak-fak West Papua. Assigning 18 respondents, this study collected data using questionnaire, interview and document and used SPSS 17.0 for analysis on multiple regression and t-test. The findings showed the significant effects existed between (1) the competence of work (X1) on the performance of employee (Y) r=0.682; p=.011; (2) the job satisfaction (X2) with the performance of employee (Y) r=0.241; p=.025; (3) the discipline of work (X3) with the performance of employee (Y) r=0.230; p=.034; and (4) the competence (X1), the job satisfaction (X2), and the discipline (X3) to the performance employee partially or simultaneously at r=0.135. A weak effect of competence, job satisfaction and discipline of work existed on the performance of employee.