摘要：Vitamin D is a prohormone nutrient, which is involved in skeletal and extra?skeletal functions. Iron is another essential nutrient that is necessary for the production of red blood cells andoxygen transport. This element plays important roles in enzymatic systems including thoserequired for Vitamin D activation. To the best of our knowledge, there is no exclusive reviewon the relationship between iron deficiency anemia (IDA), as the most prevalent type ofanemia, and Vitamin D deficiency and the effect of recovery from iron deficiency on VitaminD status. The aim of this study was to conduct a systematic search of observational andclinical trials in this field. The databases of PubMed, ProQuest, Cochrane Library, ISI Webof Knowledge, and SCOPUS were searched comprehensively. English-language humanstudies conducted on iron deficient patients or interventions on the effect of iron therapyon Vitamin D were extracted (n=10). Our initial search yielded 938 articles. A total of 23papers met the inclusion criteria. Thirteen studies were excluded because they were notrelevant or not defining anemia types. The final analysis was performed on ten articles (3cross?sectional and 7 interventional studies). Observational data indicated a positiverelationship between iron status and Vitamin D, while trials did not support the effectivenessof iron supplementation on improving Vitamin D status. The mechanism underlying thisassociation may involve the reduction of the activation of hydroxylases that yield calcitriol. Future randomized controlled trials with large sample sizes and proper designs are neededto highlight underlying mechanisms.
关键词：ANEMIA; IRON; IRON?DEFICIENCY ANEMIA; VITAMIN D; VITAMIN D DEFICIENCY
