摘要：Background: Rapid increasing prevalence of diabetes mellitus is a serious health concern inthe world. New data determined that the pathogenesis of diabetes mellitus is chronic low?gradeinflammation, resulting insulin resistance. Pomegranate seed oil (PSO) has anti?inflammatoryeffects; though it may reduce insulin resistance and improve glycemia in diabetes mellitus. Thepresent study has been designed to investigate the effects of PSO as a natural dietary componenton metabolic state of patients with Type 2 diabetes mellitus. Methods: In a randomized double?blind clinical trial study, 80 patients (28 men) with Type 2diabetes were randomly allocated to the intervention and control groups. The intervention groupconsumed PSO capsules, containing 1000 mg PSO twice daily (2000 mg PSO), whereas controlstake placebo for 8 weeks. The participants followed their previous dietary patterns and medicationuse. Dietary factors and metabolic factors including lipid profile, fasting plasma sugar, and insulinand were assayed at the baseline and after 8 weeks. Results: Participants in two intervention and control group were similar regarding anthropometricand the dietary factors at baseline and after trial (P>0.05). Mean level of total cholesterol, triglyceride, low?density lipoprotein?cholesterol, and high?density lipoprotein was not differentsignificantly between groups after trial (P>0.05). Consumption of PSO did not significantly affectthe levels of parameters such as fasting blood sugar (FBS), insulin, HbA1c, alanine transferase, and homeostasis model assessment?insulin resistance. Conclusions: Consumption of 2000mg PSO per day for 8 weeks had no effect on FBS, insulinresistance and lipid profile in diabetic patients.
