文章基本信息
- 标题：Association of the Promoter Methylation of Mitochondrial Transcription Factor A With Susceptibility to Metabolic Syndrome
- 本地全文：下载
- 作者：Mohammad Hashemi ; Hamzeh Rezaei ; Mahmoud Ali Kaykhaei 等
- 期刊名称：Gene, Cell and Tissue
- 印刷版ISSN：2345-6841
- 出版年度：2014
- 卷号：1
- 期号：1
- 页码：e18308
- DOI：10.17795/gct-18308
- 出版社：Zahedan University of Medical Sciences
- 摘要：
Background: It has been proposed that the patients with mitochondrial diseases usually manifest systemic metabolic disorders. The metabolic syndrome (MeS), a cluster of several metabolic disorders, is increasingly being recognized as a risk factor for type 2 diabetes (T2D) and cardiovascular disease.
Objectives: The aim of study was to investigate the possible association between promoter methylation of mitochondrial transcription factor A (TFAM) and MeS.
Patients and Methods: DNA was extracted from peripheral blood of 151 patients with and 149 without MeS.
Results: TFAM promoter methylation was evaluated by a nested methylation-specific PCR (nested MSP).
Conclusions: No association was found between TFAM promoter methylation and MeS. The present study suggests that the TFAM promoter methylation is not associated with risk of MeS.
- 关键词：Metabolic Syndrome X; Mitochondrial Transcription Factor A; Diabetes Mellitus; Type 2 DM
