期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2010
卷号：107
期号：14
页码：6418-6423
DOI：10.1073/pnas.1001119107
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Although the exact cause of multiple sclerosis (MS) is unknown, a number of genetic and environmental factors are thought to influence MS susceptibility. One potential environmental factor is sunlight and the subsequent production of vitamin D. A number of studies have correlated decreased exposure to UV radiation (UVR) and low serum 25-hydroxyvitamin D3 [25(OH)D3] levels with an increased risk for developing MS. Furthermore, both UVR and the active form of vitamin D, 1{alpha
